Direct reprogramming of somatic cells into induced pluripotent stem (iPS) cells is a valuable method to produce patient-specific stem cells of any lineage without the use of embryonic materials. Various new strategies have been developed to improve the reprogramming technologies since the first report of iPS cells generation from murine fibroblasts using retroviral transduction of a defined set of transcription factors. Learn more: ipsc discovery

With unrivaled expertise and experiences in various immunotherapy discovery and development, Creative Biolabs is confident in providing an integrated solution for rat RT1 genotyping service to best suit your program requirements.

Recombinant Anti-Ad fiber knob x Anti-CEA Bispecific Antibody (Tandem scFv-Fc) is designed to be expressed as a homodimer, which has 2+2 antigen-binding valency. This format consists of one Fc region and two tandem scFv fragments, in which the anti-Ad fiber knob/CEA tandem scFv is fused to the Fc domain. Learn more: Ad fiber knob CEA Tandem scFv Fc

Creative Biolabs is a leading service provider that focuses on ribosomal transcriptome research. Based on our advanced platforms and extensive experience, now we can provide novel ribosome RNA sequencing services for our clients all over the world.

Therapeutic antibodies, specifically refer to monoclonal antibodies, are bioactive antibodies with the ability to attack specific cells or proteins for the treatment of a wide variety of diseases, including cancers, immune disorders, and infections. Therapeutic antibodies have been flourishingly developing since the first therapeutic antibody, Muromonab-CD3, was approved by the Food and Administration (FDA) as an immunosuppressive agent in 1986. Learn more: non-IgG antibodies Discovery

Tumor metastasis has been considered as the major cause of the mortality of cancer patients. Meanwhile, previous studies have indicated that a group of cells has been found that are shed from primary tumors and circulating in the blood during the early stages of primary tumor formation and growth. Therefore, the detection and identification of CTCs has become a powerful tool for monitoring and preventing metastatic disease development. Moreover, CTCs sequence analysis can provide support data for clinical treatment and be used to evaluate the efficacy of systemic therapies, such as antibody therapy and targeted therapy. Learn more: ctc detection

The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Learn more: hand2 antibody

he adenosine A2A receptor (A2AR) belongs to the G protein-coupled receptor (GPCR) family A or rhodopsin receptor family. Adenosine receptors include four subtypes (A1R, A2AR, A2BR, and A3R) that are activated by extracellular adenosine. A2AR and A1R are widely distributed throughout the central nervous system and surrounding, while low-density A2BR and A3R are present in the brain. Learn more: Next-IO™ A2AR Therapeutic Monoclonal Antibody Program

Monoclonal antibody-based immunotherapies against cancer and other infectious diseases are highly advantageous comparing to conventional therapeutic approaches due to their high specificity and affinity towards well-defined targets. Antibody-drug conjugates (ADCs) inherit such superiorities and more remarkably, expand the therapeutic window of the conjugated drugs (payloads), which are usually highly toxic and diverse in their biochemical nature. Learn more: antibody drug conjugates

The sequence of nucleic acids in polynucleotide chains ultimately contains the information for the hereditary and biochemical properties of terrestrial life, which has been an important reference for in vitro diagnostics (IVD). Therefore, the ability to measure or infer DNA sequences is imperative to biological research, especially in the IVD field. Learn more: single cell sequencing

Since the commercial development of therapeutic monoclonal antibodies commenced in the early 1980s, the monoclonal antibodies have grown to become the most successful class of biotech drugs for the diagnosis and treatment against various diseases and infections. Besides the traditional IgG antibody, Creative Biolabs can help to develop Non-IgG therapeutic antibodies for our customers all over the world. Learn more: IgA Antibody Services

This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. Learn more: galnt1

If a probiotic is intended to be used as a drug for the diagnosis, treatment, mitigation, cure, or prevention of disease, it must be subject to regulatory procedures as a drug. To ensure the safety of biological agents, one of the commonly used test methods is the cytotoxicity test. Cytotoxicity tests can observe the cell growth, activity, and morphological effect of the drug in vitro. Considering the advantages of cytotoxicity testing, researchers used it as a pilot test before applying it to animals. The method proves valuable in identifying the off-target effects of certain drug compounds on the human body. Learn more: Identification of Cytotoxicity In Vitro

Fatty acids (FAs) are carboxylic acids with a long aliphatic chain, either saturated or unsaturated. FA vesicles are colloidal suspensions of closed lipid bilayers, which are composed of fatty acids and their ionized species (soap). They are observed in a small region within the fatty acid-soap-water ternary phase diagram above the chain melting temperature (Tm) of the corresponding fatty acid-soap mixture.

Astrocytes are the most abundant, numerous, and diverse type of glial cells in the central nervous system. They have a number of essential functions, e.g. physical and metabolic support for the normal functioning of neurons and other neuronal cells. An increasing number of studies have shown that astrocytes play a key role in regulating the formation of myelin sheath, which is the process of wrapping axons in myelin sheath, thereby increasing the transmission speed of electrical pulses. Learn more: Rat astrocyte cell

Alzheimer's disease (AD) presently occupies the topmost position among the most diagnosed neurodegenerative diseases worldwide, with the number of affected people forecasted to reach 100 million by 2050. According to the latest statistics, nearly 44 million people in the world suffer from AD or related dementia, with only one in four being diagnosed with the disease. Learn more: alzheimer's disease cell line

Alzheimer's disease (AD) presently occupies the topmost position among the most diagnosed neurodegenerative diseases worldwide, with the number of affected people forecasted to reach 100 million by 2050. According to the latest statistics, nearly 44 million people in the world suffer from AD or related dementia, with only one in four being diagnosed with the disease. Currently, the disease has no cure available for its treatment, except for some relief from some of the symptoms. Besides its multifactorial and heterogeneous nature, AD is also progressive, i.e., the symptoms gradually worsen with the passage of years. Multiple risk factors including genetic and environmental sources have been implicated in the emergence of AD, with advancing age being identified as the most significant among them. Learn more: cell lines for alzheimer's disease

Creative Biolabs offers a wide range of cutting-edge research products geared toward the investigation of biological processes underlying Alzheimer's disease. Our products including antibodies, cell lines, proteins & peptides, and assay kits, are among the bio-reagents keenly sought by neuroscience researchers. Learn more: Negative Regulation of Protein Kinase B Signaling

Recombinant Anti-Ad fiber knob x Anti-CEA Bispecific Antibody (Minibody) is designed to be expressed as the anti-Ad fiber knob scFv fused to N-terminus of Knob-CH3 domain and the anti-CEA scFv to the Hole-CH3 domain, or vice versa. The CH3 domains are further stabilized by C-terminal disulfide bonds. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing. Learn more: Ad fiber knob CEA Minibody

The SARS-CoV-2 is a new emerging coronavirus that has not been previously identified in humans. Outbreak of this novel coronaviruses infections among people has raised widespread attention. Treatment with RNA polymerase inhibitors is one way to help stop the virus from replicating and control the infection. Creative Biolabs provides RNA polymerase inhibitors development services for the treatment of SARS-CoV-2. Our staff has decades of experience in anti-coronaviruses drug discovery, providing high-quality, efficient and cost-effective services. Learn more: RNA Synthesis Inhibitors for SARS-CoV-2